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RU486, also known as mifepristone, is a medication used to terminate early pregnancies up to 70 days gestation. It works by
blocking the hormone progesterone, which is needed for pregnancy to continue. This causes the lining of the uterus to break
down and the pregnancy to detach from the uterine wall. RU486 is often used in combination with another medication called
misoprostol, which helps expel the pregnancy tissue from the uterus.
Generic RU486, which is also known as mifepristone, works similarly to the branded version. Here’s how it typically functions:
Blocks Progesterone: Mifepristone blocks the action of progesterone, a hormone necessary for maintaining the lining of the uterus during pregnancy. This hormone is crucial for supporting the growth of the pregnancy.
Uterine Lining Breakdown: By blocking progesterone, mifepristone causes the lining of the uterus to break down, leading to detachment of the pregnancy tissue from the uterine wall.
Contractions and Expulsion: In combination with another medication called misoprostol (often taken after mifepristone), contractions of the uterus are stimulated. This helps expel the pregnancy tissue from the uterus.
Completion of Abortion: The combination of mifepristone and misoprostol is effective for terminating pregnancies up to around 70 days (10 weeks) gestation. After taking both medications, the process typically results in the expulsion of the pregnancy tissue, similar to a miscarriage.
The dosage and intake method of RU486 (mifepristone) for medical abortion typically follow a standard protocol. Here’s how it is generally prescribed:
Mifepristone (RU486): A single oral dose of 200 milligrams (mg).
Administration: Mifepristone is taken orally, usually in a healthcare provider's office or clinic.
Timing: It is typically administered on the first day of the medical abortion process.
Day 1: Take 200 mg of mifepristone orally under medical supervision.
Day 2-3: Take 800 mcg (micrograms) of misoprostol buccally (placed in the cheek pouches) or vaginally. This medication
helps induce contractions to expel the pregnancy tissue.
After taking RU486 (mifepristone) as part of a medical abortion regimen, there are several visible symptoms and effects
that individuals may experience. It's important to note that these symptoms can vary from person to person, and not
everyone will experience all of them. Here are the common visible symptoms:
Bleeding: This is the most common symptom after taking mifepristone and misoprostol. It resembles a heavy menstrual period and is usually more intense than a regular period.
Cramping: Abdominal cramping is typical as the uterus contracts to expel the pregnancy tissue. The intensity of cramps can vary but may be quite strong during the process.
Nausea and Vomiting: Some individuals may experience nausea and vomiting, although this is less common than bleeding and cramping.
Fatigue: Feeling tired or exhausted is common during and after the abortion process.
Headaches: Headaches can occur as a side effect of the medications.
Diarrhea: Some people may experience diarrhea as a side effect of misoprostol.
Chills or Fever: Mild chills or a slight fever can occur, but these symptoms usually resolve quickly.
Passing Tissue: During the abortion process, individuals may pass blood clots and pregnancy tissue. This is a normal part of the procedure and indicates that the medications are working as intended.
Emotional Effects: Some individuals may experience emotional effects such as sadness, relief, or a range of emotions following the abortion.
These symptoms typically occur after taking misoprostol, which is taken 24 to 48 hours after mifepristone. It's important for individuals undergoing a medical abortion to be aware of these potential symptoms and to follow up with their healthcare provider as instructed for any concerns or complications.
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